Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.44 |
| ▸ | CAMKK2 | Q96RR4 | 4/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.40 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | BCR | P11274 | 3/20 | 0.39 |
| ▸ | PRKCA | P17252 | 3/20 | 0.39 |
| ▸ | C1R | P00736 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27113926 | 0.86 | PIK3CG (0.59) | MAPK8CAMKK2PIK3CGAURKAGSK3B | |
| SCHEMBL27113928 | 0.84 | CDK1 (0.54) | SMOPIK3CGAURKAGSK3BKIT | |
| SCHEMBL27114512 | 0.83 | ABL1 (0.56) | SMOPIK3CGGSK3BKITABL1 | |
| SCHEMBL27114006 | 0.83 | CCNB2 (0.52) | MAPK8CAMKK2PIK3CGAURKAGSK3B | |
| SCHEMBL27113799 | 0.81 | RET (0.52) | MAPK8CAMKK2PIK3CGGSK3BKIT | |
| SCHEMBL27113800 | 0.80 | CCNB2 (0.42) | MAPK8CAMKK2PIK3CGGSK3BKIT | |
| SCHEMBL27113933 | 0.78 | PIK3CG (0.64) | MAPK8CAMKK2PIK3CGGSK3BKIT | |
| SCHEMBL27114238 | 0.78 | CCNB2 (0.54) | MAPK8CAMKK2PIK3CGGSK3BKIT | |
| SCHEMBL27114185 | 0.78 | ABL1 (0.54) | MAPK8CAMKK2PIK3CGGSK3BCCNB2 | |
| SCHEMBL27114239 | 0.76 | PIK3CA (0.54) | PIK3CGCDK1QPCT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | claimed |
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | disclosed |
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | disclosed |