Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.57 |
| ▸ | CDK2 | P24941 | 2/20 | 0.55 |
| ▸ | CDK4 | P11802 | 1/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.54 |
| ▸ | SYK | P43405 | 2/20 | 0.53 |
| ▸ | CDC7 | O00311 | 1/20 | 0.50 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.50 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | BCR | P11274 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | CLK2 | P49760 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27115591 | 0.86 | CDK2 (0.55) | CDK2CDK4PIK3CGPIK3CACDC7 | |
| SCHEMBL27115341 | 0.85 | CLK1 (0.63) | JAK2CDK2CDK4SYKBTK | |
| SCHEMBL27115513 | 0.84 | SMO (0.60) | CDK2CDK4PIK3CGPIK3CASYK | |
| SCHEMBL30847308 | 0.84 | SMO (0.60) | CDK2CDK4PIK3CGPIK3CASYK | |
| SCHEMBL27116017 | 0.83 | CDK2 (0.54) | CDK2CDK4PIK3CGPIK3CACDC7 | |
| SCHEMBL27114880 | 0.82 | CDK4 (0.53) | CDK2CDK4PIK3CGPIK3CASYK | |
| SCHEMBL27153279 | 0.81 | CDK2 (0.52) | CDK2CDK4PIK3CGPIK3CACDC7 | |
| SCHEMBL4283784 | 0.80 | KDR (0.49) | CDK2CDK4SYK | |
| SCHEMBL28201500 | 0.80 | CLK4 (0.58) | CDK2CDK4PIK3CGPIK3CASYK | |
| SCHEMBL27116472 | 0.79 | CDK2 (0.57) | JAK2CDK2CDK4PIK3CGPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | claimed |
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | disclosed |
| WO-2024044757-A1 | AMINOPYRIMIDINE AND AMINOTRIAZINE DERIVATIVES AS MYC PROTEIN MODULATORS | Sanford Burnham Prebys Medical Discovery Institute (US) | 2024-02-29 | — | — | WO | disclosed |