Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 9/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26961944 | 1.00 | CRBN (0.37) | CRBNSMN1; SMN2KDM4EHDAC1HDAC8 | |
| SCHEMBL29797018 | 0.84 | GAA (0.38) | CRBNHDAC1HDAC8HDAC6 | |
| SCHEMBL26961679 | 0.84 | GAA (0.38) | CRBNHDAC1HDAC8HDAC6 | |
| SCHEMBL27125391 | 0.83 | KDM4E (0.33) | CRBNSMN1; SMN2KDM4EHDAC1HDAC8 | |
| SCHEMBL26962775 | 0.83 | KDM4E (0.33) | CRBNSMN1; SMN2KDM4EHDAC1HDAC8 | |
| SCHEMBL26962754 | 0.81 | HDAC1 (0.44) | SMN1; SMN2KDM4EHDAC1HDAC8HDAC6 | |
| SCHEMBL30830368 | 0.79 | HDAC1 (0.33) | CRBNSMN1; SMN2HDAC1HDAC8HDAC6 | |
| SCHEMBL27121024 | 0.74 | GAA (0.40) | CRBNSMN1; SMN2POLB | |
| SCHEMBL20263999 | 0.74 | GAA (0.40) | CRBNSMN1; SMN2POLB | |
| SCHEMBL30675755 | 0.73 | HDAC1 (0.51) | CRBNHDAC1HDAC8HDAC6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4291558-A1 | BICYCLIC TETRAHYDROAZEPINE DERIVATIVES FOR THE TREATMENT OF CANCER | F. Hoffmann-La Roche AG (CH) | 2023-12-20 | — | — | EP | disclosed |