Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.64 |
| ▸ | PIK3CA | P42336 | 17/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2712661 | 0.94 | PIK3CD (0.69) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL2712404 | 0.91 | PIK3CD (0.77) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL2713104 | 0.89 | PIK3CD (0.62) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL2712339 | 0.84 | PIK3CD (0.84) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL2711303 | 0.84 | PIK3CD (0.74) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL2712580 | 0.84 | PIK3CD (0.76) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL2713259 | 0.83 | PIK3CD (0.54) | PIK3CDPIK3CALMNAMAPTPKM | |
| SCHEMBL2713550 | 0.82 | PIK3CD (0.60) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL2711075 | 0.82 | PIK3CD (0.77) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL2711867 | 0.81 | PIK3CD (0.74) | PIK3CDPIK3CAPIK3CBPIK3CGPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445886-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151791-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |