Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.54 |
| ▸ | IRAK4 | Q9NWZ3 | 12/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2715827 | 0.91 | SYK (0.52) | SYKIRAK4JAK3 | |
| SCHEMBL2715833 | 0.91 | SYK (0.52) | SYKIRAK4JAK3 | |
| SCHEMBL2713314 | 0.84 | SYK (0.52) | SYKIRAK4JAK3 | |
| SCHEMBL2713311 | 0.84 | SYK (0.52) | SYKIRAK4JAK3 | |
| SCHEMBL2713347 | 0.83 | SYK (0.56) | SYKIRAK4 | |
| SCHEMBL2714504 | 0.82 | SYK (0.54) | SYKIRAK4JAK3 | |
| SCHEMBL2714500 | 0.82 | SYK (0.54) | SYKIRAK4JAK3 | |
| SCHEMBL14909203 | 0.81 | SYK (0.55) | SYKIRAK4JAK3 | |
| SCHEMBL2714670 | 0.80 | SYK (0.63) | SYKIRAK4JAK3 | |
| SCHEMBL2714680 | 0.80 | SYK (0.63) | SYKIRAK4JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635556-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |