Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 15/20 | 0.64 |
| ▸ | JAK1 | P23458 | 2/20 | 0.64 |
| ▸ | JAK3 | P52333 | 2/20 | 0.64 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2713336 | 0.81 | SYK (0.64) | SYKJAK1JAK3JAK2 | |
| SCHEMBL735988 | 0.78 | SYK (1.00) | SYKJAK1JAK3JAK2 | |
| SCHEMBL735989 | 0.78 | SYK (1.00) | SYKJAK1JAK3JAK2 | |
| SCHEMBL736676 | 0.78 | SYK (1.00) | SYKJAK1JAK3JAK2 | |
| SCHEMBL2693699 | 0.77 | JAK3 (0.59) | SYKJAK1JAK3JAK2 | |
| SCHEMBL2695368 | 0.77 | JAK3 (0.59) | SYKJAK1JAK3JAK2 | |
| SCHEMBL2693702 | 0.77 | JAK3 (0.59) | SYKJAK1JAK3JAK2 | |
| SCHEMBL2697565 | 0.76 | SYK (0.56) | SYKJAK1JAK3JAK2 | |
| SCHEMBL2697569 | 0.76 | SYK (0.56) | SYKJAK1JAK3JAK2 | |
| SCHEMBL737325 | 0.75 | SYK (0.75) | SYKJAK1JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635556-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | claimed |
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | claimed |