Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 11/20 | 0.55 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2713351 | 1.00 | SYK (0.55) | SYKMETALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL14908656 | 0.94 | SYK (0.56) | SYKMETALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL14908655 | 0.94 | SYK (0.56) | SYKMETALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL14929940 | 0.92 | SYK (0.61) | SYKMETALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL14910085 | 0.90 | SYK (0.54) | SYKMETALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL2715559 | 0.89 | SYK (0.56) | SYKMETALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL14909554 | 0.88 | SYK (0.54) | SYKMETALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL14909553 | 0.88 | SYK (0.54) | SYKMETALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL5026970 | 0.88 | SYK (0.58) | SYKMETNPC1MAPTPOLB | |
| SCHEMBL9108358 | 0.88 | SYK (0.58) | SYKMETNPC1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635556-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |