SCHEMBL27145199

SCHEMBL27145199

O/N=C/c1cc2cc(Br)ccc2[nH]1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 1/20 0.44
HPGD P15428 4/20 0.40
TSHR P16473 2/20 0.40
FLT3 P36888 1/20 0.39
CYP2A6 P11509 1/20 0.39
AHR P35869 1/20 0.39
NR4A2 P43354 1/20 0.39
KDR P35968 1/20 0.39
GRIN2D O15399 1/20 0.39
GRIN3B O60391 1/20 0.39
GRIN1 Q05586 1/20 0.39
GRIN2A Q12879 1/20 0.39
GRIN2B Q13224 1/20 0.39
GRIN2C Q14957 1/20 0.39
GRIN3A Q8TCU5 1/20 0.39
ALDH1A1 P00352 1/20 0.38
HRH4 Q9H3N8 1/20 0.38
HRH3 Q9Y5N1 1/20 0.38
POLB P06746 1/20 0.37
CTDSP1 Q9GZU7 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27145202 1.00 CYP19A1 (0.44) CYP19A1HPGDTSHRFLT3CYP2A6
SCHEMBL6393996 0.77 GRIN2D (0.61) HPGDFLT3CYP2A6GRIN2DGRIN3B
SCHEMBL20937653 0.77 CYP19A1 (0.47) CYP19A1FLT3CYP2A6AHRNR4A2
SCHEMBL11161856 0.77 CYP19A1 (0.47) CYP19A1HPGDFLT3CYP2A6AHR
SCHEMBL4273824 0.77 CYP2A6 (0.58) CYP19A1FLT3CYP2A6AHRNR4A2
SCHEMBL6393993 0.77 GRIN2D (0.61) HPGDFLT3CYP2A6GRIN2DGRIN3B
SCHEMBL17422776 0.74 CYP19A1 (0.45) CYP19A1FLT3CYP2A6AHRNR4A2
SCHEMBL17422778 0.74 CYP19A1 (0.45) CYP19A1FLT3CYP2A6AHRNR4A2
SCHEMBL28316268 0.71 DAO (0.49) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL4949482 0.70 CYP19A1 (0.52) CYP19A1FLT3CYP2A6AHRNR4A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260062443-A1 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS ALEXION PHARMA INC (US) 2026-03-05 US disclosed
WO-2024044098-A2 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS ALEXION PHARMACEUTICALS, INC. (US) 2024-02-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260062443-A1 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS C9, SSB, C1S CYP19A1 4832/4885HPGD 4023/4885TSHR 1164/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.