Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.46 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.36 |
| ▸ | FLT4 | P35916 | 3/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | WEE1 | P30291 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2713319 | 0.92 | SYK (0.46) | SYKJAK3AURKALCKCSF1R | |
| SCHEMBL2715319 | 0.87 | SYK (0.46) | SYKJAK3AURKAEGFRLCK | |
| SCHEMBL2712371 | 0.84 | SYK (0.47) | SYKJAK3AURKAEGFRLCK | |
| SCHEMBL2696749 | 0.80 | SYK (0.49) | SYKJAK3EGFRLCKBTK | |
| SCHEMBL2695805 | 0.79 | SYK (0.44) | SYKJAK3EGFRLCKBTK | |
| SCHEMBL2696461 | 0.78 | JAK3 (0.47) | SYKJAK3AURKACNR2 | |
| SCHEMBL2696447 | 0.78 | SYK (0.49) | SYKJAK3 | |
| SCHEMBL2697496 | 0.77 | SYK (0.52) | SYKJAK3EGFRLCKBTK | |
| SCHEMBL2696951 | 0.76 | SYK (0.48) | SYKJAK3EGFRLCKBTK | |
| SCHEMBL4403243 | 0.75 | SYK (0.52) | SYKJAK3CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635557-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061428-A2 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |