Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 9/20 | 0.40 |
| ▸ | RAF1 | P04049 | 8/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3490624 | 0.78 | PIK3CA (0.62) | — | |
| SCHEMBL2961095 | 0.77 | EGLN2 (0.47) | EGLN2CA12CA1CA9CYP17A1 | |
| SCHEMBL29529712 | 0.77 | EGLN2 (0.47) | EGLN2CA12CA1CA9CYP17A1 | |
| SCHEMBL25261217 | 0.74 | GSK3B (0.42) | EGLN2ATRMAPKAPK2 | |
| SCHEMBL30154943 | 0.74 | BDKRB1 (0.42) | ATR | |
| SCHEMBL21567684 | 0.74 | BDKRB1 (0.42) | ATR | |
| SCHEMBL30293080 | 0.74 | SMARCA2 (0.57) | CA12CA1CA9CYP17A1ATR | |
| SCHEMBL16055308 | 0.74 | SMARCA2 (0.57) | CA12CA1CA9CYP17A1ATR | |
| SCHEMBL1501665 | 0.74 | SMARCA2 (0.57) | CA12CA1CA9CYP17A1ATR | |
| SCHEMBL18989458 | 0.74 | ATR (0.39) | IDH1CA12CA1CA9CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4578852-A1 | HETEROCYCLIC COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL USE THEREOF | Jiangsu Hengrui Pharmaceuticals Co., Ltd. (CN) | 2025-07-02 | — | — | EP | disclosed |
| WO-2024041613-A1 | HETEROCYCLIC COMPOUND, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL USE THEREOF | 江苏恒瑞医药股份有限公司 | 2024-02-29 | — | — | WO | disclosed |
| CN-111196804-A | TGF- β R1 inhibitor and application thereof | 南京圣和药业股份有限公司 | 2020-05-26 | — | — | CN | disclosed |