Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 10/20 | 0.50 |
| ▸ | FER | P16591 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2732111 | 0.93 | SYK (0.49) | SYKFERMEN1NPC1POLB | |
| SCHEMBL2732113 | 0.93 | SYK (0.49) | SYKFERMEN1NPC1POLB | |
| SCHEMBL2716964 | 0.91 | SYK (0.49) | SYKFERMEN1NPC1POLB | |
| SCHEMBL2716959 | 0.91 | SYK (0.49) | SYKFERMEN1NPC1POLB | |
| SCHEMBL10250632 | 0.84 | SYK (0.53) | SYKFERMEN1NPC1POLB | |
| SCHEMBL2715588 | 0.81 | SYK (0.54) | SYKFERMEN1NPC1POLB | |
| SCHEMBL2715587 | 0.81 | SYK (0.54) | SYKFERMEN1NPC1POLB | |
| SCHEMBL5027760 | 0.80 | SYK (0.52) | SYKFERJAK2JAK1ALDH1A1 | |
| SCHEMBL2732114 | 0.80 | SYK (0.52) | SYKFERMEN1NPC1POLB | |
| SCHEMBL9236196 | 0.80 | SYK (0.52) | SYKFERJAK2JAK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635556-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | Portola Pharmaceuticals, Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061418-A2 | BENZAMIDES AND NICOTINAMIDES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |