Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | LPL | P06858 | 8/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 8/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | CA9 | Q16790 | 3/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA3 | P07451 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29914758 | 1.00 | PRMT5 (0.44) | PRMT5WDR77IDO1TDO2LPL | |
| SCHEMBL20227582 | 0.79 | PRMT5 (0.46) | PRMT5WDR77IDO1TDO2LPL | |
| SCHEMBL20227576 | 0.76 | PARP1 (0.44) | PRMT5WDR77IDO1TDO2LPL | |
| SCHEMBL20227578 | 0.76 | PARP1 (0.50) | PRMT5WDR77LPLLIPGCSF1R | |
| SCHEMBL27157743 | 0.75 | KDM4E (0.47) | PRMT5WDR77IDO1TDO2LPL | |
| SCHEMBL29914853 | 0.75 | PRMT5 (0.46) | PRMT5WDR77IDO1TDO2LPL | |
| SCHEMBL30041886 | 0.75 | KDM4E (0.47) | PRMT5WDR77IDO1TDO2LPL | |
| SCHEMBL27159644 | 0.75 | PRMT5 (0.46) | PRMT5WDR77IDO1TDO2LPL | |
| SCHEMBL29914854 | 0.75 | PRMT5 (0.46) | PRMT5WDR77IDO1TDO2LPL | |
| SCHEMBL20227547 | 0.74 | PARP1 (0.50) | PRMT5WDR77LPLLIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4330246-A1 | HALO-SUBSTITUTED AMINO AZA-HETEROARYL COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | Ontario Institute for Cancer Research (OICR) (CA) | 2024-03-06 | — | — | EP | disclosed |
| CN-117597336-A | Halogen substituted amino aza-heteroaryl compounds as inhibitors of hematopoietic progenitor kinase 1 (HPK 1) | 安大略省癌症研究所(OICR) | 2024-02-23 | — | — | CN | disclosed |