Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 5/20 | 0.53 |
| ▸ | TACR3 | P29371 | 4/20 | 0.35 |
| ▸ | GCG | P01275 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | DCAF1 | Q9Y4B6 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2715090 | 0.89 | CAPN1 (0.43) | CAPN1CRHR1CRHR2DCAF1MAP4K4 | |
| SCHEMBL2716408 | 0.88 | CAPN1 (0.69) | CAPN1TACR3CNR1CNR2 | |
| SCHEMBL2715483 | 0.88 | CAPN1 (0.51) | CAPN1TACR3 | |
| SCHEMBL2714925 | 0.87 | CAPN1 (0.53) | CAPN1 | |
| SCHEMBL2715518 | 0.86 | CAPN1 (0.59) | CAPN1SLC6A9MAP4K4CNR1CNR2 | |
| SCHEMBL2716990 | 0.85 | CAPN1 (0.58) | CAPN1DCAF1SLC6A9CNR2 | |
| SCHEMBL2715422 | 0.83 | CAPN1 (0.54) | CAPN1SLC6A9CNR1CNR2 | |
| SCHEMBL16551487 | 0.82 | CAPN1 (0.77) | CAPN1TACR3GCGDCAF1 | |
| SCHEMBL2714449 | 0.82 | CAPN1 (0.59) | CAPN1CNR1CNR2 | |
| Hydrochloric Acid SCHEMBL541203 | 0.82 | CAPN1 (0.75) | CAPN1TACR3GCGDCAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238130-B1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2012-05-02 | — | — | EP | claimed |
| EP-2238130-B1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | ABBOTT GMBH & CO KG (DE) | 2012-05-02 | — | — | EP | disclosed |
| EP-2238130-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | Abbott GmbH & Co. KG (DE) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009083581-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2009-07-09 | — | — | WO | disclosed |