SCHEMBL27165490

SCHEMBL27165490

CC(C)(C)CC[C@H](NCc1cccc(Oc2ccccc2)c1)C(=O)O

nearest known ligand 0.51

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 12/20 0.51
GRN P28799 1/20 0.49
SORT1 Q99523 1/20 0.49
MME P08473 1/20 0.47
ACE P12821 1/20 0.47
CPA1 P15085 1/20 0.47
ACE2 Q9BYF1 1/20 0.47
PTGES O14684 1/20 0.46
GNA15 P30679 1/20 0.45
PTGER3 P43115 1/20 0.45
FFAR4 Q5NUL3 1/20 0.45
TDP1 Q9NUW8 1/20 0.45
KDM4E B2RXH2 1/20 0.44
ALDH1A1 P00352 1/20 0.44
HTT P42858 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27165689 1.00 FFAR1 (0.51) FFAR1GRNSORT1MMEACE
SCHEMBL30903297 0.89 MEN1 (0.51) ALDH1A1HTTSMN1; SMN2
SCHEMBL29213358 0.89 MEN1 (0.51) ALDH1A1HTTSMN1; SMN2
SCHEMBL29213363 0.89 MEN1 (0.51) ALDH1A1HTTSMN1; SMN2
SCHEMBL27165628 0.89 GRN (0.52) FFAR1GRNSORT1MMEACE
SCHEMBL27165541 0.89 GRN (0.52) FFAR1GRNSORT1MMEACE
SCHEMBL30903308 0.85 GRN (0.46) GRNSORT1
SCHEMBL27165674 0.83 GRN (0.55) FFAR1GRNSORT1
SCHEMBL27165513 0.83 GRN (0.55) FFAR1GRNSORT1
Hydrochloric Acid SCHEMBL30219109 0.83 GRN (0.45) GRNSORT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4580750-A1 SORTILIN MODULATORS Vesper Bio Aps (DK) 2025-07-09 EP claimed
CN-120077033-A Sortilin modulators 维斯珀生物应用有限公司 2025-05-30 CN claimed
EP-4342530-A1 SORTILIN MODULATORS Insusense ApS (DK) 2024-03-27 EP claimed
WO-2024047227-A1 SORTILIN MODULATORS INSUSENSE ApS (DK) 2024-03-07 WO claimed
EP-4580750-A1 SORTILIN MODULATORS Vesper Bio Aps (DK) 2025-07-09 EP disclosed
CN-120077033-A Sortilin modulators 维斯珀生物应用有限公司 2025-05-30 CN disclosed
EP-4342530-A1 SORTILIN MODULATORS Insusense ApS (DK) 2024-03-27 EP disclosed
WO-2024047227-A1 SORTILIN MODULATORS INSUSENSE ApS (DK) 2024-03-07 WO disclosed