Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 14/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2716824 | 0.87 | GRM5 (1.00) | GRM5ALDH1A1HTTMAOAMAOB | |
| SCHEMBL2715105 | 0.86 | GRM5 (0.79) | GRM5ALDH1A1HTTMAOAMAOB | |
| SCHEMBL2716589 | 0.83 | GRM5 (0.77) | GRM5 | |
| SCHEMBL2714863 | 0.83 | GRM5 (0.77) | GRM5ALDH1A1HTT | |
| SCHEMBL2713356 | 0.82 | GRM5 (0.69) | GRM5ALDH1A1HTTMAOAMAOB | |
| SCHEMBL2714445 | 0.82 | GRM5 (0.76) | GRM5ALDH1A1HTT | |
| SCHEMBL2717904 | 0.82 | GRM5 (0.76) | GRM5ALDH1A1HTTMAOAMAOB | |
| SCHEMBL2716289 | 0.82 | GRM5 (0.76) | GRM5ALDH1A1HTTMAOAMAOB | |
| SCHEMBL2716000 | 0.82 | GRM5 (0.76) | GRM5ALDH1A1HTT | |
| SCHEMBL2715287 | 0.82 | GRM5 (0.76) | GRM5ALDH1A1HTTMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012052451-A1 | METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-04-26 | — | — | WO | disclosed |