Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 1/20 | 0.52 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.52 |
| ▸ | ZAP70 | P43403 | 5/20 | 0.46 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25123673 | 0.93 | CDK5 (0.53) | CDK5CDK5R1ZAP70MAPK3SYK | |
| SCHEMBL29991260 | 0.93 | CDK5 (0.53) | CDK5CDK5R1ZAP70MAPK3SYK | |
| SCHEMBL25123656 | 0.91 | CDK5 (0.55) | CDK5CDK5R1ZAP70SYKALK | |
| SCHEMBL22520990 | 0.87 | CDK5 (0.47) | CDK5CDK5R1ZAP70MAPK3SYK | |
| SCHEMBL22521162 | 0.86 | CDK5 (0.55) | CDK5CDK5R1ZAP70SYKIGF1R | |
| SCHEMBL31105062 | 0.85 | CDK5 (0.52) | CDK5CDK5R1ZAP70SYKALK | |
| SCHEMBL29172717 | 0.85 | ZAP70 (0.49) | CDK5CDK5R1ZAP70SYKALK | |
| SCHEMBL29172732 | 0.84 | CDK5 (0.46) | CDK5CDK5R1ZAP70MAPK3SYK | |
| SCHEMBL25122528 | 0.84 | CDK5 (0.46) | CDK5CDK5R1ZAP70MAPK3SYK | |
| SCHEMBL30872653 | 0.83 | ZAP70 (0.45) | CDK5CDK5R1ZAP70SYKALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117715904-A | CDK2 degrading agents and uses thereof | 凯麦拉医疗公司 | 2024-03-15 | — | — | CN | disclosed |
| EP-4334307-A1 | CDK2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-03-13 | — | — | EP | disclosed |
| WO-2022236058-A1 | CDK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |