Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 15/20 | 0.60 |
| ▸ | CCND1 | P24385 | 14/20 | 0.60 |
| ▸ | CDK4 | P11802 | 12/20 | 0.60 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.60 |
| ▸ | CCND3 | P30281 | 5/20 | 0.58 |
| ▸ | CCND2 | P30279 | 4/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.53 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.53 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.53 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.48 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.48 |
| ▸ | PRKDC | P78527 | 3/20 | 0.48 |
| ▸ | CDK9 | P50750 | 3/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | TTK | P33981 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29991292 | 1.00 | CDK2 (0.60) | CDK2CCND1CDK4CCNA2CCND3 | |
| SCHEMBL25122980 | 0.90 | CDK2 (0.57) | CDK2CCND1CDK4CCNA2CCND3 | |
| SCHEMBL29990907 | 0.90 | CDK2 (0.57) | CDK2CCND1CDK4CCNA2CCND3 | |
| SCHEMBL29991084 | 0.87 | CDK2 (0.58) | CDK2CCND1CDK4CCNA2CCND3 | |
| SCHEMBL25122998 | 0.87 | CDK2 (0.58) | CDK2CCND1CDK4CCNA2CCND3 | |
| SCHEMBL29991661 | 0.86 | CCND1 (0.57) | CDK2CCND1CDK4CCNA2CCND3 | |
| SCHEMBL25123329 | 0.86 | CCND1 (0.57) | CDK2CCND1CDK4CCNA2CCND3 | |
| SCHEMBL25122544 | 0.83 | CDK2 (0.59) | CDK2CCND1CDK4CCNA2CCND3 | |
| SCHEMBL27358069 | 0.82 | CDK2 (0.58) | CDK2CCND1CDK4CCNA2CCND3 | |
| SCHEMBL27358813 | 0.81 | CDK2 (0.55) | CDK2CCND1CDK4CCNA2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4334307-A1 | CDK2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-03-13 | — | — | EP | disclosed |