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SCHEMBL27166407

SCHEMBL27166407

Cn1c(=O)n(C2CCC(=O)NC2=O)c2cccc(C#CCCCCCn3cc(CC(=O)OC(C)(C)C)cn3)c21

nearest known ligand 0.39

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 13/20 0.39
▸ DDB1 Q16531 12/20 0.39
▸ IRAK4 Q9NWZ3 2/20 0.36
▸ STAT3 P40763 1/20 0.35
▸ BRD3 Q15059 3/20 0.34
▸ HDAC6 Q9UBN7 1/20 0.33
▸ GSK3B P49841 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25122886 0.90 CRBN (0.39) CRBNDDB1IRAK4STAT3BRD3
SCHEMBL27166534 0.87 CRBN (0.41) CRBNDDB1
SCHEMBL29991108 0.87 DDB1 (0.43) CRBNDDB1IRAK4STAT3GSK3B
SCHEMBL25123324 0.87 DDB1 (0.43) CRBNDDB1IRAK4STAT3GSK3B
SCHEMBL25122889 0.82 DDB1 (0.45) CRBNDDB1
SCHEMBL29347154 0.82 CRBN (0.41) CRBNDDB1IRAK4STAT3HDAC6
SCHEMBL23842301 0.81 CRBN (0.48) CRBNDDB1STAT3HDAC6
SCHEMBL25123321 0.81 CRBN (0.48) CRBNDDB1STAT3HDAC6
SCHEMBL29991197 0.81 CRBN (0.48) CRBNDDB1STAT3HDAC6
SCHEMBL25123840 0.81 CRBN (0.48) CRBNDDB1STAT3HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4334307-A1 CDK2 DEGRADERS AND USES THEREOF Kymera Therapeutics, Inc. (US) 2024-03-13 — — EP disclosed
WO-2022236058-A1 CDK2 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2022-11-10 — — WO disclosed
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