Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 18/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | AKT2 | P31751 | 1/20 | 0.32 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27166508 | 0.85 | CRBN (0.45) | CRBNDDB1JAK2 | |
| SCHEMBL27166534 | 0.83 | CRBN (0.41) | CRBNDDB1JAK2 | |
| SCHEMBL30169288 | 0.79 | CRBN (0.54) | CRBNDDB1 | |
| SCHEMBL22526770 | 0.79 | CRBN (0.54) | CRBNDDB1 | |
| SCHEMBL30169156 | 0.79 | CRBN (0.54) | CRBNDDB1 | |
| SCHEMBL25123384 | 0.79 | CRBN (0.54) | CRBNDDB1 | |
| SCHEMBL30169198 | 0.79 | CRBN (0.54) | CRBNDDB1 | |
| SCHEMBL30990811 | 0.79 | CRBN (0.54) | CRBNDDB1 | |
| SCHEMBL22526772 | 0.79 | CRBN (0.54) | CRBNDDB1 | |
| SCHEMBL22526201 | 0.79 | CRBN (0.54) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4334307-A1 | CDK2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-03-13 | — | — | EP | disclosed |