Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CFTR | P13569 | 9/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27167731 | 0.89 | CFTR (0.43) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL23303990 | 0.80 | MEN1 (0.41) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL27167927 | 0.78 | CFTR (0.42) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL23304256 | 0.74 | CFTR (0.49) | CFTRWNT3A | |
| SCHEMBL23303716 | 0.74 | BTK (0.47) | L3MBTL1CDK1PIM1MAPKAPK2GSK3A | |
| SCHEMBL27167851 | 0.69 | CFTR (0.43) | L3MBTL1KDM4ECFTRPOLBBTK | |
| SCHEMBL23336436 | 0.69 | CFTR (0.46) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL29840296 | 0.69 | CFTR (0.46) | MEN1KMT2AL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL16794160 | 0.66 | MKNK1 (0.48) | BTKWNT3A | |
| SCHEMBL23303691 | 0.65 | BTK (0.56) | MEN1KMT2AL3MBTL1POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4333899-A1 | COMPOUNDS FOR TARGETING DEGRADATION OF BRUTON'S TYROSINE KINASE | Biogen MA Inc. (US) | 2024-03-13 | — | — | EP | disclosed |