Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 7/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 2/20 | 0.34 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6128775 | 0.92 | GRM1 (0.41) | PIK3CDPIK3CBPIK3CGPIK3CAGRM1 | |
| SCHEMBL2717294 | 0.89 | DHODH (0.40) | RORCPLA2G2ADHODHPRNP | |
| SCHEMBL2719961 | 0.89 | PIK3CD (0.45) | PIK3CDPIK3CBPIK3CGPIK3CAGRM1 | |
| SCHEMBL2716749 | 0.88 | PIK3CD (0.43) | PIK3CDPIK3CBPIK3CGPIK3CAGRM1 | |
| SCHEMBL2716874 | 0.86 | PIK3CD (0.48) | PIK3CDPIK3CBPIK3CGPIK3CAGRM1 | |
| SCHEMBL2717639 | 0.85 | PIK3CD (0.51) | PIK3CDPIK3CBPIK3CGPIK3CAGRM1 | |
| SCHEMBL6121707 | 0.85 | PIK3CD (0.44) | PIK3CDPIK3CBPIK3CGPIK3CAGRM1 | |
| SCHEMBL6122094 | 0.84 | PIK3CD (0.42) | PIK3CDPIK3CBPIK3CGPIK3CAGRM1 | |
| SCHEMBL2718639 | 0.83 | PIK3CD (0.44) | PIK3CDPIK3CBPIK3CGPIK3CAGRM1 | |
| SCHEMBL6123048 | 0.83 | PIK3CD (0.35) | PIK3CDPIK3CBPIK3CGPIK3CAGRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445900-A2 | POLYCYCLIC DERIVATIVES OF PYRIDINE AND THEIR USE IN THE TREATMENT OF (INTER ALIA) RHEUMATOID ARTHRITIS AND SIMILAR DISEASES | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151740-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |