Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 16/20 | 0.76 |
| ▸ | SULT1A1 | P50225 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29453199 | 1.00 | APP (0.76) | APPSULT1A1MAPTHTTTP53 | |
| SCHEMBL2055221 | 0.95 | APP (0.84) | APPSULT1A1MAPTHTT | |
| SCHEMBL2055207 | 0.86 | APP (1.00) | APPSULT1A1MAPT | |
| SCHEMBL27173130 | 0.85 | MAPT (0.63) | APPMAPTTP53THRBSMN1; SMN2 | |
| SCHEMBL29453145 | 0.85 | MAPT (0.63) | APPMAPTTP53THRBSMN1; SMN2 | |
| SCHEMBL2055230 | 0.83 | APP (0.69) | APPSULT1A1MAPT | |
| SCHEMBL1754280 | 0.83 | APP (1.00) | APPSULT1A1MAPTHTT | |
| SCHEMBL29453174 | 0.83 | APP (0.60) | APPSULT1A1MAPTHTT | |
| SCHEMBL27173172 | 0.83 | APP (0.60) | APPSULT1A1MAPTHTT | |
| SCHEMBL21752044 | 0.81 | APP (1.00) | APPSULT1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4337259-A1 | COMPOUNDS FOR DEGRADING ALPHA-SYNUCLEIN AGGREGATES AND USES THEREOF | Aprinoia Therapeutics Limited (HK) | 2024-03-20 | — | — | EP | disclosed |
| WO-2022238737-A1 | COMPOUNDS FOR DEGRADING ALPHA-SYNUCLEIN AGGREGATES AND USES THEREOF | APRINOIA THERAPEUTICS LIMITED (CN) | 2022-11-17 | — | — | WO | disclosed |