Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.66 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16202734 | 0.85 | SYK (0.66) | SYKMAPK8MAPK9AURKBNPC1 | |
| SCHEMBL2627366 | 0.83 | SYK (0.62) | SYKMAPK8MAPK9NPC1RAB9A | |
| SCHEMBL2627261 | 0.80 | SYK (1.00) | SYKMAPK8MAPK9AURKBNPC1 | |
| SCHEMBL2716637 | 0.80 | NPC1 (0.63) | SYKMAPK8NPC1RAB9AMEN1 | |
| SCHEMBL13624991 | 0.79 | SYK (0.68) | SYKMAPK8AURKB | |
| SCHEMBL16782402 | 0.79 | SYK (0.63) | SYKMAPK8MAPK9AURKBNPC1 | |
| SCHEMBL18926157 | 0.78 | SYK (0.57) | SYKMAPK8NPC1RAB9AMEN1 | |
| SCHEMBL14977146 | 0.78 | SYK (0.75) | SYK | |
| SCHEMBL16194907 | 0.78 | SYK (0.75) | SYK | |
| SCHEMBL2713766 | 0.77 | SYK (0.56) | SYKMAPK8NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061415-A1 | OXYPYRIMIDINES AS SYK MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |