Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 19/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL890502 | 0.81 | PIK3CD (0.77) | PIK3CD | |
| SCHEMBL2717496 | 0.77 | PIK3CD (0.48) | PIK3CDTP53GAASMN1; SMN2 | |
| SCHEMBL890736 | 0.75 | PIK3CD (0.78) | PIK3CD | |
| SCHEMBL2728306 | 0.74 | PIK3CD (0.65) | PIK3CD | |
| SCHEMBL17397103 | 0.74 | PIK3CD (0.53) | PIK3CD | |
| SCHEMBL890543 | 0.72 | PIK3CD (0.60) | PIK3CD | |
| SCHEMBL2716944 | 0.71 | PIK3CD (0.66) | PIK3CD | |
| SCHEMBL977356 | 0.71 | PIK3CD (0.68) | PIK3CD | |
| SCHEMBL977963 | 0.71 | PIK3CD (0.77) | PIK3CD | |
| SCHEMBL17165550 | 0.71 | PIK3CD (0.56) | PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445898-A2 | 4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE DERIVATIVES AS PI3K INHIBITORS | Amgen, Inc (US) | 2012-05-02 | — | — | EP | claimed |
| WO-2010151735-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | claimed |