Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SCD | O00767 | 1/20 | 0.30 |
| ▸ | PI4KA | P42356 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2717351 | 0.85 | IDO1 (0.34) | KCNA5TSHRPIK3CGPIK3CDMAPK14 | |
| SCHEMBL2718963 | 0.81 | — | — | |
| SCHEMBL2718966 | 0.81 | — | — | |
| SCHEMBL2717695 | 0.80 | CBFB (0.44) | PIK3CGPIK3CDMAPK14 | |
| SCHEMBL2717748 | 0.78 | TYK2 (0.35) | TSHRPIK3CGJAK1TYK2MAPK14 | |
| SCHEMBL2717350 | 0.77 | PIK3CD (0.41) | KCNA5PIK3CGPIK3CDMAPK14SCD | |
| SCHEMBL2717044 | 0.77 | MAPK14 (0.31) | MAPK14 | |
| SCHEMBL2717042 | 0.77 | MAPK14 (0.31) | MAPK14 | |
| SCHEMBL2718211 | 0.76 | PIK3CG (0.33) | PIK3CGPIK3CDMAPK14PI4KA | |
| SCHEMBL2720253 | 0.73 | PIK3CD (0.49) | PIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445900-A2 | POLYCYCLIC DERIVATIVES OF PYRIDINE AND THEIR USE IN THE TREATMENT OF (INTER ALIA) RHEUMATOID ARTHRITIS AND SIMILAR DISEASES | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151740-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |