Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 20/20 | 0.72 |
| ▸ | PIK3CB | P42338 | 19/20 | 0.72 |
| ▸ | PIK3CG | P48736 | 19/20 | 0.72 |
| ▸ | PIK3CA | P42336 | 16/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2717070 | 0.92 | PIK3CD (0.72) | PIK3CDPIK3CBPIK3CGPIK3CACYP2D6 | |
| SCHEMBL2718262 | 0.88 | PIK3CD (0.59) | PIK3CDPIK3CBPIK3CGPIK3CACYP2D6 | |
| SCHEMBL2717814 | 0.86 | PIK3CD (0.62) | PIK3CDPIK3CBPIK3CGPIK3CACYP2D6 | |
| SCHEMBL1695119 | 0.85 | PIK3CD (0.60) | PIK3CDPIK3CBPIK3CGPIK3CACYP2D6 | |
| SCHEMBL2717998 | 0.85 | PIK3CD (0.70) | PIK3CDPIK3CBPIK3CGPIK3CACYP2D6 | |
| SCHEMBL2718949 | 0.85 | PIK3CD (0.58) | PIK3CDPIK3CBPIK3CGPIK3CACYP2D6 | |
| SCHEMBL2718938 | 0.84 | PIK3CD (0.58) | PIK3CDPIK3CBPIK3CGPIK3CACYP2D6 | |
| SCHEMBL6122150 | 0.84 | PIK3CD (0.65) | PIK3CDPIK3CBPIK3CGPIK3CACYP2D6 | |
| SCHEMBL2717460 | 0.84 | PIK3CD (0.61) | PIK3CDPIK3CBPIK3CGPIK3CACYP2D6 | |
| SCHEMBL2719999 | 0.84 | PIK3CD (0.63) | PIK3CDPIK3CBPIK3CGPIK3CACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445900-A2 | POLYCYCLIC DERIVATIVES OF PYRIDINE AND THEIR USE IN THE TREATMENT OF (INTER ALIA) RHEUMATOID ARTHRITIS AND SIMILAR DISEASES | Amgen, Inc (US) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010151740-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |