⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2716287 | 0.91 | — | — | |
| SCHEMBL2715021 | 0.90 | — | — | |
| SCHEMBL2716364 | 0.88 | — | — | |
| SCHEMBL13014822 | 0.88 | — | — | |
| SCHEMBL2718987 | 0.88 | — | — | |
| SCHEMBL2716184 | 0.88 | — | — | |
| SCHEMBL2715081 | 0.87 | — | — | |
| SCHEMBL13014844 | 0.86 | — | — | |
| SCHEMBL2716551 | 0.86 | — | — | |
| SCHEMBL13014853 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445868-A2 | NOVEL BIPHENYL AND PHENYL-PYRIDINE AMIDES | F. Hoffmann-La Roche AG (CH) | 2012-05-02 | — | — | EP | claimed |
| WO-2010149578-A2 | NOVEL BIPHENYL AND PHENYL-PYRIDINE AMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-12-29 | — | — | WO | claimed |
| US-20170057932-A1 | BIPHENYL AND PHENYL-PYRIDINE AMIDES AS P2X3 AND P2X2/3 ANTAGONISTS | ROCHE PALO ALTO LLC (US) | 2017-03-02 | — | — | US | disclosed |
| US-9505726-B2 | Substituted biphenyl amides as P2X3 and P2X2/3 antagonists | ROCHE PALO ALTO LLC (US) | 2016-11-29 | — | — | US | disclosed |
| US-20150080408-A1 | PYRIDINYL AMIDES AS P2X3 AND P2X2/3 INHIBITORS | ROCHE PALO ALTO LLC (US) | 2015-03-19 | — | — | US | disclosed |
| US-8895589-B2 | Pyridinyl amides as P2X3 and P2X2/3 inhibitors | ROCHE PALO ALTO LLC (US) | 2014-11-25 | — | — | US | disclosed |
| US-20130165443-A1 | BIPHENYL AND PHENYL-PYRIDINE AMIDES AS P2X3 AND P2X2/3 ANTAGONISTS | BROKA CHRIS ALLEN (US) | 2013-06-27 | — | — | US | disclosed |
| US-8283383-B2 | Biphenyl amides as P2X3 and P2X2/3 antagonists | ROCHE PALO ALTO LLC (US) | 2012-10-09 | — | — | US | disclosed |
| US-8283383-B2 | Biphenyl amides as P2X3 and P2X2/3 antagonists | ROCHE PALO ALTO LLC (US) | 2012-10-09 | — | — | US | disclosed |
| WO-2010149578-A2 | NOVEL BIPHENYL AND PHENYL-PYRIDINE AMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-12-29 | — | — | WO | disclosed |
| US-20100324056-A1 | BIPHENYL AND PHENYL-PYRIDINE AMIDES AS P2X3 AND P2X2/3 ANTAGONISTS | BROKA CHRIS ALLEN | 2010-12-23 | — | — | US | disclosed |
| US-20100324056-A1 | BIPHENYL AND PHENYL-PYRIDINE AMIDES AS P2X3 AND P2X2/3 ANTAGONISTS | BROKA CHRIS ALLEN | 2010-12-23 | — | — | US | disclosed |