Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 10/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.33 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CDK7 | P50613 | 1/20 | 0.31 |
| ▸ | CCNH | P51946 | 1/20 | 0.31 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.31 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.31 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29760080 | 1.00 | POLQ (0.39) | POLQNTRK1CDK9CCNT1HSD17B13 | |
| SCHEMBL29760162 | 0.91 | POLQ (0.37) | POLQNTRK1CDK9CCNT1KIT | |
| SCHEMBL29759447 | 0.91 | POLQ (0.37) | POLQNTRK1CDK9CCNT1KIT | |
| SCHEMBL24579069 | 0.91 | POLQ (0.37) | POLQNTRK1CDK9CCNT1KIT | |
| SCHEMBL27185021 | 0.91 | POLQ (0.37) | POLQNTRK1KITCHRM1PDGFRA | |
| SCHEMBL29760155 | 0.91 | POLQ (0.37) | POLQNTRK1KITCHRM1PDGFRA | |
| SCHEMBL27184984 | 0.91 | POLQ (0.37) | POLQNTRK1KITCHRM1PDGFRA | |
| SCHEMBL29759887 | 0.91 | POLQ (0.37) | POLQNTRK1KITCHRM1PDGFRA | |
| SCHEMBL29759606 | 0.89 | POLQ (0.37) | POLQNTRK1CDK9CCNT1KIT | |
| SCHEMBL29759976 | 0.89 | POLQ (0.37) | POLQNTRK1CDK9CCNT1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240109917-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2024-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240109917-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | PDGFRA, PDGFRB, ABL1 | POLQ 2881/4885NTRK1 127/4885CDK9 269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.