Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 11/20 | 0.79 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.67 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | TP53 | P04637 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27188332 | 0.93 | PPARG (0.85) | PPARGCYP2C8PTGS2MAPTTP53 | |
| SCHEMBL27188685 | 0.92 | PPARG (0.78) | PPARGCYP2C8PTGS2MAPTTP53 | |
| SCHEMBL27188686 | 0.89 | PPARG (0.79) | PPARGCYP2C8PTGS2MAPTTP53 | |
| SCHEMBL27188266 | 0.88 | PPARG (1.00) | PPARGCYP2C8PTGS2MAPTTP53 | |
| SCHEMBL27188292 | 0.88 | PPARG (1.00) | PPARGCYP2C8PTGS2MAPTTP53 | |
| SCHEMBL27188326 | 0.88 | PPARG (0.81) | PPARGCYP2C8PTGS2MAPTTP53 | |
| SCHEMBL27188290 | 0.88 | PPARG (0.85) | PPARGCYP2C8PTGS2MAPTTP53 | |
| SCHEMBL27188334 | 0.86 | PPARG (0.76) | PPARGCYP2C8PTGS2MAPTTP53 | |
| SCHEMBL27188323 | 0.86 | PPARG (0.84) | PPARGCYP2C8PTGS2MAPTSMN1; SMN2 | |
| SCHEMBL27188270 | 0.85 | PPARG (1.00) | PPARGCYP2C8PTGS2MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240109850-A1 | Covalent PPARG inverse-agonists | BAYER AKTIENGESELLSCHAFT (DE) | 2024-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240109850-A1 | Covalent PPARG inverse-agonists | PPARG, PPARD, PPARA | PPARG 1/4885CYP2C8 839/4885PTGS2 499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.