Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | UNG | P13051 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 4/20 | 0.42 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4612423 | 0.86 | HTT (0.77) | HTTNPC1RAB9ASMN1; SMN2HDAC8 | |
| SCHEMBL6946370 | 0.80 | HTT (0.68) | HTTNPC1RAB9ASMN1; SMN2HDAC8 | |
| N-Piperidinobenzamide SCHEMBL696161 | 0.77 | HTT (1.00) | HTTNPC1RAB9ASMN1; SMN2CYP2C9 | |
| SCHEMBL9282775 | 0.77 | HTT (1.00) | HTTNPC1RAB9ASMN1; SMN2CYP2C9 | |
| SCHEMBL279859 | 0.77 | HTT (0.63) | HTTNPC1RAB9ASMN1; SMN2HDAC8 | |
| SCHEMBL1471436 | 0.77 | HPGD (0.62) | HTTUNGNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7698519 | 0.77 | HTT (0.63) | HTTNPC1RAB9ASMN1; SMN2HDAC8 | |
| Ammonia Solution, Strong SCHEMBL28325092 | 0.76 | HPGD (0.60) | HTTUNGNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2399935 | 0.76 | HTT (0.96) | HTTNPC1RAB9ASMN1; SMN2HDAC8 | |
| SCHEMBL15650472 | 0.75 | HPGD (0.61) | HTTUNGSMN1; SMN2LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133888-B2 | Hydrazide containing taxane conjugates | SUN PHARMA ADVANCED RESEARCH COMPANY LTD. (IN) | 2012-03-13 | — | — | US | disclosed |
| US-8133888-B2 | Hydrazide containing taxane conjugates | SUN PHARMA ADVANCED RESEARCH COMPANY LTD. (IN) | 2012-03-13 | — | — | US | disclosed |
| US-20110172226-A1 | NOVEL HYDRAZIDE CONTAINING TAXANE CONJUGATES | SUN PHARMA ADVANCED RESEARCH COMPANY LTD. (IN) | 2011-07-14 | — | — | US | disclosed |
| US-20110172226-A1 | NOVEL HYDRAZIDE CONTAINING TAXANE CONJUGATES | SUN PHARMA ADVANCED RESEARCH COMPANY LTD. (IN) | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172226-A1 | NOVEL HYDRAZIDE CONTAINING TAXANE CONJUGATES | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, H1-3, H1-5 | HTT 154/4885UNG 3553/4885NPC1 2919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.