Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 0.54 |
| ▸ | S1PR5 | Q9H228 | 5/20 | 0.53 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.53 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.48 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.48 |
| ▸ | GPR183 | P32249 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2134073 | 0.99 | S1PR1 (0.54) | S1PR1S1PR5S1PR3S1PR2S1PR4 | |
| SCHEMBL2135178 | 0.98 | S1PR1 (0.55) | S1PR1S1PR5S1PR3S1PR2S1PR4 | |
| SCHEMBL2138457 | 0.96 | S1PR1 (0.55) | S1PR1S1PR5S1PR3S1PR2S1PR4 | |
| SCHEMBL2143589 | 0.91 | S1PR1 (0.54) | S1PR1S1PR5S1PR3S1PR2S1PR4 | |
| SCHEMBL2136114 | 0.90 | S1PR1 (0.56) | S1PR1S1PR5S1PR3S1PR2S1PR4 | |
| SCHEMBL12975475 | 0.89 | S1PR1 (0.51) | S1PR1S1PR5S1PR3 | |
| SCHEMBL2134359 | 0.89 | S1PR1 (0.55) | S1PR1S1PR5S1PR3S1PR2S1PR4 | |
| SCHEMBL2133593 | 0.89 | S1PR1 (0.56) | S1PR1S1PR5S1PR3S1PR2S1PR4 | |
| SCHEMBL2134908 | 0.88 | S1PR1 (0.56) | S1PR1S1PR5S1PR3S1PR2S1PR4 | |
| SCHEMBL2134299 | 0.88 | S1PR1 (0.55) | S1PR1S1PR5S1PR3S1PR2S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445892-A1 | 5-MEMBERED HETEROARYL DERIVATIVES USED AS SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONISTS | Glaxo Group Limited (GB) | 2012-05-02 | — | — | EP | claimed |
| WO-2010148650-A1 | 5-MEMBERED HETEROARYL DERIVATIVES USED AS SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2010-12-29 | — | — | WO | claimed |