Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Chenodiol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 known ✓ | Q96RI1 | 7/20 | 1.00 |
| ▸ | GPBAR1 | Q8TDU6 | 14/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | SLC10A2 | Q12908 | 2/20 | 1.00 |
| ▸ | ENPP2 | Q13822 | 2/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 1.00 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chenodiol SCHEMBL22079588 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4ABCB11MEN1KMT2A | |
| Chenodiol SCHEMBL24199134 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4ABCB11MEN1KMT2A | |
| Chenodiol SCHEMBL23517166 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4ABCB11MEN1KMT2A | |
| Chenodiol SCHEMBL22079179 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4ABCB11MEN1KMT2A | |
| Chenodiol SCHEMBL25337643 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4ABCB11MEN1KMT2A | |
| Chenodiol SCHEMBL24124587 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4ABCB11MEN1KMT2A | |
| Chenodiol SCHEMBL25397934 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4ABCB11MEN1KMT2A | |
| Chenodiol SCHEMBL24061005 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4ABCB11MEN1KMT2A | |
| Chenodiol SCHEMBL23704676 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4ABCB11MEN1KMT2A | |
| Chenodiol SCHEMBL25337648 | 1.00 | GPBAR1 (1.00) | GPBAR1NR1H4ABCB11MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 21705 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260146992-A1 | INTESTINAL BIOMARKERS FOR GUT HEALTH IN DOMESTICATED BIRDS | INTERNATIONAL N&H DENMARK APS (DK) | 2026-05-28 | — | — | US | claimed |
| US-20260146298-A1 | INTESTINAL BIOMARKERS FOR GUT HEALTH IN DOMESTICATED BIRDS | INTERNATIONAL N&H DENMARK APS (DK) | 2026-05-28 | — | — | US | claimed |
| CN-122075501-A | Application of tauroursodeoxycholic acid in inhibiting alpha-glucosidase activity | — | 2026-05-26 | — | — | CN | claimed |
| CN-122070923-A | Clostridium abalone preparation and application thereof in treatment of pet diseases | 广州源博医药科技有限公司 | 2026-05-22 | — | — | CN | claimed |
| US-20260137680-A1 | NOVEL COMPOUNDS | SITRYX THERAPEUTICS LTD (GB) | 2026-05-21 | — | — | US | claimed |
| US-20260138973-A1 | SUBSTITUTED PYRIDINES FOR USE IN TREATING OR PREVENTING INFLAMMATORY DISEASES OR DISEASES ASSOCIATED WITH AN UNDESIRABLE IMMUNE RESPONSE | SITRYX THERAPEUTICS LTD (GB) | 2026-05-21 | — | — | US | claimed |
| CN-122056832-A | Ursodeoxycholic acid-hyaluronic acid nanoemulsion and application thereof in treatment of inflammatory bowel disease | 安徽医科大学 | 2026-05-19 | — | — | CN | claimed |
| CN-122070128-A | Primary biliary nature treatment of cholangitis | 基恩菲特公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122060831-A | Method and device for generating ursodeoxycholic acid by continuous flow catalytic chenodeoxycholic acid | 南京师范大学 | 2026-05-19 | — | — | CN | claimed |
| CN-122031352-A | Nanometer compound hirudin protein line for remodelling glycolipid metabolism and preparation method thereof | 山东第一医科大学(山东省医学科学院) | 2026-05-15 | — | — | CN | claimed |
| US-4379093-A | Process for preparing high purity ursodeoxycholic acid | ERREGIERRE S.P.A. (IT) | 1983-04-05 | — | — | US | claimed |
| EP-0063106-A1 | Process for preparing high purity ursodeoxycholic acid | ERREGIERRE S.p.A. (IT) | 1982-10-20 | — | — | EP | claimed |
| US-4316848-A | Process for the purification of ursodeoxycholic acid | BLASINACHIM S.P.A (IT) | 1982-02-23 | — | — | US | claimed |
| US-4303754-A | ENZYMATIC SYNTHESIS USING CLOSTRIDIUM | MACDONALD, LINDA (CA) | 1981-12-01 | — | — | US | claimed |
| US-4264583-A | POLYOL-FATTY ACID ESTER AND A LITHOLYTIC BILE ACID | THE PROCTER & GAMBLE COMPANY (US) | 1981-04-28 | — | — | US | claimed |
| US-4263272-A | FOR LYSIS OF CHOLESTEROL CALCULI | LEHNER AG (CH) | 1981-04-21 | — | — | US | claimed |
| EP-0024292-A1 | Process for the separation of ursodeoxycholic acid from chenodeoxycholic acid and products obtained during the process | BLASCHIM S.p.A. (IT) | 1981-03-04 | — | — | EP | claimed |
| EP-0023375-A1 | Gall-stone dissolution compositions | THE PROCTER & GAMBLE COMPANY (US) | 1981-02-04 | — | — | EP | claimed |
| US-4185099-A | ANTIDANDRUFF AGENTS | Also Laboratori S.a.S. di Dr.P. Sorbini & C (IT) | 1980-01-22 | — | — | US | claimed |
| US-3969503-A | STEROID | INTELLECTUAL PROPERTY DEVELOPMENT CORPORATION (US) | 1976-07-13 | — | — | US | claimed |