SCHEMBL27201014

SCHEMBL27201014

CC(C)(C)OC(=O)N1CC[C@@H](N(C(=O)c2ccc(B3OC(C)(C)C(C)(C)O3)cc2)c2ncccc2Cl)C1

nearest known ligand 0.51

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
USP30 Q70CQ3 2/20 0.51
MEN1 O00255 3/20 0.45
KMT2A Q03164 3/20 0.45
GPR119 Q8TDV5 15/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27201015 1.00 USP30 (0.51) USP30MEN1KMT2AGPR119
SCHEMBL16187373 0.95 USP30 (0.48) USP30MEN1KMT2AGPR119
SCHEMBL16187375 0.87 USP30 (0.46) USP30MEN1KMT2AGPR119
SCHEMBL27200993 0.85 USP30 (0.51) USP30MEN1KMT2AGPR119
SCHEMBL27200999 0.85 USP30 (0.51) USP30MEN1KMT2AGPR119
SCHEMBL16177501 0.84 PCSK9 (0.43)
SCHEMBL16187386 0.82 USP30 (0.45) USP30MEN1KMT2AGPR119
SCHEMBL16625309 0.81 USP30 (0.66) USP30GPR119
SCHEMBL16177338 0.80 USP30 (0.45) USP30MEN1KMT2AGPR119
SCHEMBL16177340 0.80 USP30 (0.45) USP30MEN1KMT2AGPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4357345-A1 CLY SERIES COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF IN PREPARATION OF DRUGS Nanjing Wellbest Pharmaceutical Co., Ltd (CN) 2024-04-24 EP disclosed
CN-113248501-B CLY series compounds, preparation method thereof and application thereof in preparing medicines 南京韦尔优众医药有限公司 2021-10-08 CN disclosed
CN-113248501-A CLY series compounds, preparation method thereof and application thereof in preparing medicines 南京韦尔优众医药有限公司 2021-08-13 CN disclosed