Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 5/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2722268 | 0.94 | DRD3 (0.42) | DRD3DRD2HTR1AKCNH2CYP2D6 | |
| SCHEMBL2722066 | 0.92 | DRD3 (0.44) | DRD3DRD2HTR1AKCNH2CHRM2 | |
| SCHEMBL2720512 | 0.89 | DRD3 (0.42) | DRD3DRD2HTR1AKCNH2MAPT | |
| SCHEMBL2720580 | 0.89 | DRD3 (0.41) | DRD3DRD2HTR1AMAPK1TP53 | |
| SCHEMBL2721839 | 0.88 | DRD3 (0.43) | DRD3DRD2HTR1AKCNH2TP53 | |
| SCHEMBL900249 | 0.87 | MAPT (0.42) | DRD3DRD2KCNH2MAPTTP53 | |
| SCHEMBL2720730 | 0.86 | DRD3 (0.41) | DRD3DRD2HTR1AKCNH2MAPT | |
| SCHEMBL2721632 | 0.86 | DRD3 (0.42) | DRD3DRD2HTR1AKCNH2CYP2D6 | |
| SCHEMBL2722101 | 0.85 | DRD3 (0.43) | DRD3DRD2HTR1AKCNH2HRH3 | |
| SCHEMBL2720427 | 0.85 | DRD3 (0.41) | DRD3DRD2HTR1AKCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621916-B1 | BENZAZOLE DERIVATIVES AS HISTAMINE H4 RECEPTOR LIGANDS | BIOPROJET SOC CIV (FR) | 2016-02-10 | — | — | EP | claimed |
| EP-2447263-A1 | Benzazole derivatives as histamine H4 receptor ligands | BIOPROJET (FR) | 2012-05-02 | — | — | EP | claimed |