SCHEMBL27217151

SCHEMBL27217151

Cn1ncc(-c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)c1-c1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 10/20 0.60
▸ IKZF1 Q13422 3/20 0.55
▸ CSNK1A1 P48729 1/20 0.54
▸ IKZF2 Q9UKS7 7/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27317312 0.99 CRBN (0.59) CRBNIKZF1CSNK1A1IKZF2
SCHEMBL27317314 0.94 CRBN (0.60) CRBNIKZF1CSNK1A1IKZF2
SCHEMBL27315986 0.93 CRBN (0.56) CRBNIKZF1CSNK1A1IKZF2
SCHEMBL27316988 0.92 CRBN (0.66) CRBNIKZF1CSNK1A1IKZF2
SCHEMBL27317308 0.92 CRBN (0.66) CRBNIKZF1CSNK1A1IKZF2
SCHEMBL27322113 0.92 CRBN (0.55) CRBNIKZF1IKZF2
SCHEMBL27216930 0.92 CRBN (0.55) CRBNIKZF1IKZF2
SCHEMBL27317146 0.91 CRBN (0.56) CRBNIKZF1CSNK1A1IKZF2
SCHEMBL27316090 0.91 CRBN (0.56) CRBNIKZF1CSNK1A1IKZF2
SCHEMBL27311175 0.91 CRBN (0.54) CRBNIKZF1IKZF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4584259-A1 CK1ALPHA AND DUAL CK1ALPHA / GSPT1 DEGRADING COMPOUNDS Innovo Therapeutics, Inc. (US) 2025-07-16 — — EP disclosed
US-20240158370-A1 CK1 alpha AND DUAL CK1 alpha / GSPT1 DEGRADING COMPOUNDS INNOVO THERAPEUTICS, INC. 2024-05-16 — — US disclosed
WO-2024054832-A1 CK1α AND DUAL CK1α / GSPT1 DEGRADING COMPOUNDS INNOVO THERAPEUTICS, INC. (US) 2024-03-14 — — WO disclosed
WO-2024054832-A1 CK1α AND DUAL CK1α / GSPT1 DEGRADING COMPOUNDS INNOVO THERAPEUTICS, INC. (US) 2024-03-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240158370-A1 CK1 alpha AND DUAL CK1 alpha / GSPT1 DEGRADING COMPOUNDS CKS1B, CKS2, MARK1 CRBN 764/4885IKZF1 3493/4885CSNK1A1 5/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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