Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | CBFB | Q13951 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2720785 | 0.79 | CBFB (0.37) | MAPK14CBFB | |
| SCHEMBL2722154 | 0.78 | TNF (0.38) | MAPK14TNFCBFB | |
| SCHEMBL2719784 | 0.73 | CBFB (0.36) | MAPK14CBFB | |
| SCHEMBL2721186 | 0.72 | RXFP1 (0.32) | CBFB | |
| SCHEMBL2721188 | 0.72 | RXFP1 (0.32) | CBFB | |
| SCHEMBL2720154 | 0.71 | PIK3CD (0.48) | — | |
| SCHEMBL2718747 | 0.71 | FFAR1 (0.36) | — | |
| SCHEMBL2720782 | 0.69 | CCR1 (0.38) | MAPK14TNFCBFB | |
| SCHEMBL2718326 | 0.69 | PIK3CD (0.33) | TNF | |
| SCHEMBL2721580 | 0.68 | PIK3CD (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2635565-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | Amgen Inc. (US) | 2013-09-11 | — | — | EP | disclosed |
| WO-2012061696-A1 | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | AMGEN INC. (US) | 2012-05-10 | — | — | WO | disclosed |