Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 10/20 | 0.35 |
| ▸ | IKZF2 | Q9UKS7 | 5/20 | 0.34 |
| ▸ | GSPT1 | P15170 | 2/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 2/20 | 0.34 |
| ▸ | WIZ | O95785 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL27231854 | 0.79 | IKZF2 (0.54) | CRBNIKZF2GSPT1DDB1CYP2C19 | |
| SCHEMBL27302543 | 0.75 | CRBN (0.59) | CRBNIKZF2ESR1WIZCSNK1A1 | |
| SCHEMBL24675552 | 0.75 | CRBN (0.59) | CRBNIKZF2ESR1WIZCSNK1A1 | |
| SCHEMBL27424055 | 0.73 | IKZF2 (0.56) | CRBNIKZF2ESR1WIZCSNK1A1 | |
| SCHEMBL28638497 | 0.71 | IKZF2 (0.66) | IKZF2 | |
| SCHEMBL27302697 | 0.71 | CRBN (0.55) | CRBNIKZF2ESR1WIZCSNK1A1 | |
| SCHEMBL26495770 | 0.70 | CRBN (0.38) | CRBNIKZF2ESR1WIZHTR2A | |
| SCHEMBL22557823 | 0.70 | CRBN (0.32) | CRBNIKZF2GSPT1DDB1CYP2C19 | |
| SCHEMBL26101937 | 0.70 | KDM4E (0.32) | CRBNDDB1 | |
| SCHEMBL20235035 | 0.70 | CRBN (0.56) | CRBNIKZF2ESR1WIZCSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240174637-A1 | DEGRADERS OF GRK2 AND USES THEREOF | PIIZZI GRAZIA (US) | 2024-05-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240174637-A1 | DEGRADERS OF GRK2 AND USES THEREOF | GRK2, GRK3, GRK1 | CRBN 1066/4885IKZF2 3569/4885GSPT1 568/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.