Pochonin E

Pochonin E

SCHEMBL2722774

CC1C/C=C/C(O)C/C=C/C(=O)Cc2c(Cl)c(O)cc(O)c2C(=O)O1

nearest known ligand 0.75

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AB1 P08238 4/20 0.75
MAPT P10636 3/20 0.57
HSP90AA1 P07900 2/20 0.57
GAA P10253 1/20 0.57
RAB9A P51151 1/20 0.57
NPSR1 Q6W5P4 1/20 0.57
NLRP3 Q96P20 1/20 0.57
CBR1 P16152 1/20 0.57
PTGS2 P35354 1/20 0.57
ACLY P53396 1/20 0.57
FTO Q9C0B1 1/20 0.57
MEN1 O00255 1/20 0.57
ALDH1A1 P00352 1/20 0.57
HPGD P15428 1/20 0.57
KMT2A Q03164 1/20 0.57
F13A1 P00488 1/20 0.46
TGM2 P21980 1/20 0.46
FLT3 P36888 6/20 0.44
KIT P10721 6/20 0.44
PDGFRA P16234 6/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pochonin E SCHEMBL10133616 1.00 HSP90AB1 (0.75) HSP90AB1MAPTHSP90AA1GAARAB9A
Pochonin E SCHEMBL4513895 1.00 HSP90AB1 (0.75) HSP90AB1MAPTHSP90AA1GAARAB9A
Pochonin E SCHEMBL15451779 1.00 HSP90AB1 (0.75) HSP90AB1MAPTHSP90AA1GAARAB9A
SCHEMBL19027121 0.90 HSP90AB1 (0.60) HSP90AB1MAPTHSP90AA1GAARAB9A
SCHEMBL15448075 0.88 HSP90AB1 (0.58) HSP90AB1MAPTHSP90AA1GAARAB9A
SCHEMBL15448092 0.88 HSP90AB1 (0.58) HSP90AB1MAPTHSP90AA1GAARAB9A
SCHEMBL15448082 0.88 HSP90AB1 (0.58) HSP90AB1MAPTHSP90AA1GAARAB9A
Pochonin D SCHEMBL669590 0.86 HSP90AB1 (1.00) HSP90AB1MAPTHSP90AA1GAARAB9A
Pochonin D SCHEMBL4513578 0.86 HSP90AB1 (1.00) HSP90AB1MAPTHSP90AA1GAARAB9A
Pochonin D SCHEMBL2683508 0.86 HSP90AB1 (1.00) HSP90AB1MAPTHSP90AA1GAARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107011311-A Pochoxime conjugates for treating HSP90 related pathologies 斯特拉斯堡大学 2017-08-04 CN disclosed
US-20170174669-A1 POCHOXIME CONJUGATES USEFUL FOR THE TREATMENT OF HSP90 RELATED PATHOLOGIES UNIV STRASBOURG (FR) 2017-06-22 US disclosed
US-20150374680-A1 POCHOXIME CONJUGATES USEFUL FOR THE TREATMENT OF HSP90 RELATED PATHOLOGIES UNIVERSITE DE STRASBOURG (FR) 2015-12-31 US disclosed
US-20140031302-A1 POCHOXIME CONJUGATES USEFUL FOR THE TREATMENT OF HSP90 RELATED PATHOLOGIES UNIVERSITE DE STRASBOURG (FR) 2014-01-30 US disclosed
CN-103370311-A Pochoxime conjugates for the treatment of HSP 90-related conditions UNIV STRASBOURG 2013-10-23 CN disclosed
EP-2630132-A1 POCHOXIME CONJUGATES USEFUL FOR THE TREATMENT OF HSP90 RELATED PATHOLOGIES Université de Strasbourg (FR) 2013-08-28 EP disclosed
WO-2012052843-A1 POCHOXIME CONJUGATES USEFUL FOR THE TREATMENT OF HSP90 RELATED PATHOLOGIES UNIVERSITE DE STRASBOURG (FR) 2012-04-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170174669-A1 POCHOXIME CONJUGATES USEFUL FOR THE TREATMENT OF HSP90 RELATED PATHOLOGIES HSP90AB2P, HSP90AB1, HSP90AA1 HSP90AB1 2/4885MAPT 1022/4885HSP90AA1 3/4885
US-20150374680-A1 POCHOXIME CONJUGATES USEFUL FOR THE TREATMENT OF HSP90 RELATED PATHOLOGIES HSP90AB2P, HSP90AB1, HSP90AA1 HSP90AB1 2/4885MAPT 978/4885HSP90AA1 3/4885
US-20140031302-A1 POCHOXIME CONJUGATES USEFUL FOR THE TREATMENT OF HSP90 RELATED PATHOLOGIES HSP90AB2P, HSP90AB1, HSP90AA1 HSP90AB1 2/4885MAPT 1022/4885HSP90AA1 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.