⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL417089 | 0.72 | — | — | |
| SCHEMBL1074378 | 0.72 | — | — | |
| Nitromethane SCHEMBL7743069 | 0.67 | — | — | |
| Nitromethane SCHEMBL9065960 | 0.67 | — | — | |
| SCHEMBL8622641 | 0.62 | — | — | |
| SCHEMBL57162 | 0.62 | — | — | |
| Nitromethane SCHEMBL525 | 0.62 | — | — | |
| Nitromethane SCHEMBL17162023 | 0.59 | — | — | |
| Nitromethane SCHEMBL10735049 | 0.59 | — | — | |
| SCHEMBL4140734 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234918-A1 | AUTOMATED DIAZOMETHANE GENERATOR, REACTOR AND SOLID PHASE QUENCHER | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2023-07-27 | — | — | US | claimed |
| EP-4178942-A1 | AUTOMATED DIAZOMETHANE GENERATOR, REACTOR AND SOLID PHASE QUENCHER | Council Of Scientific & Industrial Research (IN) | 2023-05-17 | — | — | EP | claimed |
| WO-2022044038-A1 | AUTOMATED DIAZOMETHANE GENERATOR, REACTOR AND SOLID PHASE QUENCHER | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2022-03-03 | — | — | WO | claimed |
| US-9573896-B2 | Methods for preparing d-threo-methylphenidate using diazomethane, and compositions thereof | AMPAC FINE CHEMICALS LLC (US) | 2017-02-21 | — | — | US | claimed |
| US-20160090356-A1 | METHODS FOR PREPARING D-THREO-METHYLPHENIDATE USING DIAZOMETHANE, AND COMPOSITIONS THEREOF | AMPAC FINE CHEMICALS LLC | 2016-03-31 | — | — | US | claimed |
| US-9233924-B2 | Methods for preparing D-threo methylphenidate using diazomethane, and compositions thereof | AMPAC FINE CHEMICALS LLC (US) | 2016-01-12 | — | — | US | claimed |
| US-20150259289-A1 | METHODS FOR PREPARING D-THREO METHYLPHENIDATE USING DIAZOMETHANE, AND COMPOSITIONS THEREOF | AMPAC FINE CHEMICALS LLC (US) | 2015-09-17 | — | — | US | claimed |
| EP-0916649-B1 | Large scale batch process for diazomethane | AEROJET FINE CHEMICALS LLC (US) | 2002-01-23 | — | — | EP | claimed |
| EP-0916648-B1 | Continuous process for diazomethane | AEROJET FINE CHEMICALS LLC (US) | 2002-01-23 | — | — | EP | claimed |
| EP-0916648-A1 | Continuous process for diazomethane | AEROJET-GENERAL CORPORATION (US) | 1999-05-19 | — | — | EP | claimed |
| EP-0916649-A1 | Large scale batch process for diazomethane | AEROJET-GENERAL CORPORATION (US) | 1999-05-19 | — | — | EP | claimed |
| US-5854405-A | Continuous process for diazomethane from an n-methyl-n-nitrosoamine and from methylurea through n-methyl-n-nitrosourea | AEROJET-GENERAL CORPORATION (US) | 1998-12-29 | — | — | US | claimed |
| US-5817778-A | FROM AN N-METHYL-N-NITROSOAMINE, PHASE TRANSFER CATALYST | AEROJET-GENERAL CORPORATION (US) | 1998-10-06 | — | — | US | claimed |
| US-20230234918-A1 | AUTOMATED DIAZOMETHANE GENERATOR, REACTOR AND SOLID PHASE QUENCHER | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2023-07-27 | — | — | US | disclosed |
| EP-4178942-A1 | AUTOMATED DIAZOMETHANE GENERATOR, REACTOR AND SOLID PHASE QUENCHER | Council Of Scientific & Industrial Research (IN) | 2023-05-17 | — | — | EP | disclosed |
| WO-2022044038-A1 | AUTOMATED DIAZOMETHANE GENERATOR, REACTOR AND SOLID PHASE QUENCHER | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2022-03-03 | — | — | WO | disclosed |
| US-5854405-A | Continuous process for diazomethane from an n-methyl-n-nitrosoamine and from methylurea through n-methyl-n-nitrosourea | AEROJET-GENERAL CORPORATION (US) | 1998-12-29 | — | — | US | disclosed |
| US-5854405-A | Continuous process for diazomethane from an n-methyl-n-nitrosoamine and from methylurea through n-methyl-n-nitrosourea | AEROJET-GENERAL CORPORATION (US) | 1998-12-29 | — | — | US | disclosed |
| US-5817778-A | FROM AN N-METHYL-N-NITROSOAMINE, PHASE TRANSFER CATALYST | AEROJET-GENERAL CORPORATION (US) | 1998-10-06 | — | — | US | disclosed |
| US-5817778-A | FROM AN N-METHYL-N-NITROSOAMINE, PHASE TRANSFER CATALYST | AEROJET-GENERAL CORPORATION (US) | 1998-10-06 | — | — | US | disclosed |