Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A1 | P43005 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SI | P14410 | 1/20 | 0.38 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GRM8 | O00222 | 1/20 | 0.34 |
| ▸ | GRM6 | O15303 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL131050 | 0.88 | SLC1A1 (0.55) | SLC1A1TSHRLMNAKDM4EMGAM | |
| SCHEMBL131049 | 0.88 | SLC1A1 (0.55) | SLC1A1TSHRLMNAKDM4EMGAM | |
| SCHEMBL1318285 | 0.88 | SLC1A1 (0.55) | SLC1A1TSHRLMNAKDM4EMGAM | |
| Hydrochloric Acid SCHEMBL624145 | 0.86 | SLC1A1 (0.53) | SLC1A1TSHRLMNAKDM4EMGAM | |
| SCHEMBL28180863 | 0.86 | SLC1A1 (0.53) | SLC1A1TSHRLMNAKDM4EMGAM | |
| Hydrochloric Acid SCHEMBL624146 | 0.86 | SLC1A1 (0.53) | SLC1A1TSHRLMNAKDM4EMGAM | |
| Hydrochloric Acid SCHEMBL1238805 | 0.86 | SLC1A1 (0.53) | SLC1A1TSHRLMNAKDM4EMGAM | |
| SCHEMBL1373976 | 0.85 | SLC1A1 (0.38) | SLC1A1LMNALTA4HKMT2AGRM8 | |
| SCHEMBL648219 | 0.85 | SLC1A1 (0.38) | SLC1A1LMNALTA4HKMT2AGRM8 | |
| SCHEMBL3510151 | 0.85 | SLC1A1 (0.38) | SLC1A1LMNALTA4HKMT2AGRM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9029501-B2 | Method for making macrocycles | RIGEL PHARMACEUTICALS, INC. (US) | 2015-05-12 | — | — | US | disclosed |
| US-20130217874-A1 | METHOD FOR MAKING MACROCYCLES | RIGEL PHARMACEUTICALS, INC. (US) | 2013-08-22 | — | — | US | disclosed |
| WO-2012061408-A2 | METHOD FOR MAKING MACROCYCLES | RIGEL PHARMACEUTICALS. INC. (US) | 2012-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130217874-A1 | METHOD FOR MAKING MACROCYCLES | EZR, SQLE, CBR3 | SLC1A1 4704/4885TSHR 3677/4885LMNA 1935/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.