Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 7/20 | 0.48 |
| ▸ | ROS1 | P08922 | 3/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.46 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | INSR | P06213 | 2/20 | 0.46 |
| ▸ | EML4 | Q9HC35 | 2/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | FER | P16591 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.44 |
| ▸ | BLK | P51451 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.44 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.44 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30223020 | 1.00 | EGFR (0.51) | EGFRALKROS1LRRK2MAPK3 | |
| SCHEMBL27076029 | 0.88 | EGFR (0.51) | EGFRALKROS1LRRK2MAPK3 | |
| SCHEMBL29624110 | 0.84 | EGFR (0.67) | EGFRALKROS1MAPK3INSR | |
| SCHEMBL22806726 | 0.84 | EGFR (0.67) | EGFRALKROS1MAPK3INSR | |
| SCHEMBL27076044 | 0.84 | EGFR (0.48) | EGFRALKROS1LRRK2MAPK3 | |
| SCHEMBL22819299 | 0.84 | EGFR (0.54) | EGFRALKROS1INSREML4 | |
| SCHEMBL26379006 | 0.79 | EGFR (0.51) | EGFRALK | |
| SCHEMBL27076049 | 0.79 | EGFR (0.51) | EGFRALKROS1LRRK2MAPK3 | |
| SCHEMBL27076036 | 0.79 | EGFR (0.74) | EGFRALKLRRK2 | |
| SCHEMBL27076030 | 0.79 | EGFR (0.74) | EGFRALKMETINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4382514-A1 | PYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING SAME AS ACTIVE INGREDIENT | Korea Research Institute of Chemical Technology (KR) | 2024-06-12 | — | — | EP | disclosed |