Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Salicylanilide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.89 |
| ▸ | MEN1 | O00255 | 5/20 | 0.89 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.89 |
| ▸ | TP53 | P04637 | 4/20 | 0.89 |
| ▸ | HTT | P42858 | 4/20 | 0.89 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.89 |
| ▸ | HPGD | P15428 | 3/20 | 0.89 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.89 |
| ▸ | POLB | P06746 | 2/20 | 0.77 |
| ▸ | NPC1 | O15118 | 3/20 | 0.72 |
| ▸ | RAB9A | P51151 | 2/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.72 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.72 |
| ▸ | RELA | Q04206 | 1/20 | 0.72 |
| ▸ | PNLIP | P16233 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.61 |
| ▸ | CA9 | Q16790 | 1/20 | 0.61 |
| ▸ | FADS1 | O60427 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylanilide SCHEMBL152221 | 0.94 | MEN1 (1.00) | LMNAMEN1KMT2ATP53HTT | |
| Salicylanilide SCHEMBL14051034 | 0.94 | MEN1 (1.00) | LMNAMEN1KMT2ATP53HTT | |
| Salicylanilide SCHEMBL28262329 | 0.94 | MEN1 (1.00) | LMNAMEN1KMT2ATP53HTT | |
| Salicylanilide SCHEMBL20165864 | 0.94 | MEN1 (1.00) | LMNAMEN1KMT2ATP53HTT | |
| Salicylanilide SCHEMBL28868416 | 0.92 | MEN1 (0.96) | LMNAMEN1KMT2ATP53HTT | |
| Salicylanilide SCHEMBL5377091 | 0.92 | MEN1 (0.96) | LMNAMEN1KMT2ATP53HTT | |
| Salicylanilide SCHEMBL2968865 | 0.92 | MEN1 (0.96) | LMNAMEN1KMT2ATP53HTT | |
| Salicylanilide SCHEMBL5801955 | 0.92 | MEN1 (0.96) | LMNAMEN1KMT2ATP53HTT | |
| Salicylanilide SCHEMBL28474195 | 0.92 | MEN1 (0.96) | LMNAMEN1KMT2ATP53HTT | |
| Salicylanilide SCHEMBL9300362 | 0.92 | MEN1 (0.96) | LMNAMEN1KMT2ATP53HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024126426-A1 | HALOGENATED SALICYLANILIDE DERIVATIVES AS USP8 INHIBITORS FOR THERAPEUTIC USES | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2024-06-20 | — | — | WO | disclosed |
| EP-4385513-A1 | HALOGENATED SALICYLANILIDE DERIVATIVES AS USP8 INHIBITORS FOR THERAPEUTIC USES | Commissariat à l'Energie Atomique et aux Energies Alternatives (FR) | 2024-06-19 | — | — | EP | disclosed |