Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PRKDC | P78527 | 6/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.35 |
| ▸ | MAT2A | P31153 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2731944 | 0.86 | SMN1; SMN2 (0.51) | SMN1; SMN2PIK3CAPRKDCKDM4EALDH1A1 | |
| SCHEMBL8408289 | 0.86 | PI4KB (0.48) | SMN1; SMN2PIK3CAPRKDCKDM4EALDH1A1 | |
| SCHEMBL2727144 | 0.85 | SMN1; SMN2 (0.47) | SMN1; SMN2PIK3CAPRKDCKDM4EALDH1A1 | |
| SCHEMBL2726605 | 0.84 | SMN1; SMN2 (0.47) | SMN1; SMN2PIK3CAPRKDCKDM4EALDH1A1 | |
| SCHEMBL8408288 | 0.84 | SMN1; SMN2 (0.48) | SMN1; SMN2PIK3CAPRKDCKDM4EALDH1A1 | |
| SCHEMBL2726476 | 0.82 | SMN1; SMN2 (0.53) | SMN1; SMN2PIK3CAPRKDCKDM4EALDH1A1 | |
| SCHEMBL2726036 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2PIK3CAPRKDCALDH1A1GAA | |
| SCHEMBL8408337 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2PIK3CAPRKDCKDM4EALDH1A1 | |
| SCHEMBL8408334 | 0.79 | SMN1; SMN2 (0.58) | SMN1; SMN2PIK3CAPRKDCKDM4EALDH1A1 | |
| SCHEMBL2726335 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2PIK3CAPRKDCKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012058671-A1 | SUBSTITUTED QUINAZOLINE AND PYRIDO-PYRIMIDINE DERIVATIVES | ENDO PHARMACEUTICALS INC. (US) | 2012-05-03 | — | — | WO | disclosed |