Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.43 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.38 |
| ▸ | CPT1A | P50416 | 5/20 | 0.37 |
| ▸ | CPT2 | P23786 | 4/20 | 0.37 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.36 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | TSPO | P30536 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TACR3 | P29371 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10290124 | 1.00 | BACE1 (0.43) | BACE1BACE2TRPV1HCRTR1HCRTR2 | |
| SCHEMBL2726071 | 1.00 | BACE1 (0.43) | BACE1BACE2TRPV1HCRTR1HCRTR2 | |
| SCHEMBL2726179 | 1.00 | BACE1 (0.43) | BACE1BACE2TRPV1HCRTR1HCRTR2 | |
| SCHEMBL2725504 | 0.95 | BACE1 (0.42) | BACE1BACE2TRPV1HCRTR1HCRTR2 | |
| SCHEMBL2725505 | 0.95 | BACE1 (0.42) | BACE1BACE2TRPV1HCRTR1HCRTR2 | |
| SCHEMBL2725501 | 0.95 | BACE1 (0.42) | BACE1BACE2TRPV1HCRTR1HCRTR2 | |
| SCHEMBL2728527 | 0.94 | BACE1 (0.43) | BACE1BACE2TRPV1HCRTR1HCRTR2 | |
| SCHEMBL2727234 | 0.94 | BACE1 (0.43) | BACE1BACE2TRPV1HCRTR1HCRTR2 | |
| SCHEMBL2728525 | 0.94 | BACE1 (0.43) | BACE1BACE2TRPV1HCRTR1HCRTR2 | |
| SCHEMBL2728521 | 0.94 | BACE1 (0.43) | BACE1BACE2TRPV1HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054510-A1 | OXADIAZOLE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |