Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.41 |
| ▸ | HTR2C | P28335 | 7/20 | 0.41 |
| ▸ | HTR2B | P41595 | 6/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22025397 | 0.88 | HTR2A (0.40) | HTR2AHTR2CHTR2BHTR1ACYP3A4 | |
| SCHEMBL22342696 | 0.88 | HTR2A (0.44) | HTR2AHTR2CHTR2BHTR1ACYP3A4 | |
| SCHEMBL22342695 | 0.84 | HTR2A (0.38) | HTR2AHTR2CHTR2BHTR1ACYP3A4 | |
| SCHEMBL31401783 | 0.82 | NPC1 (0.41) | HTR2AHTR2CHTR2BHTR1ACYP3A4 | |
| SCHEMBL16664687 | 0.82 | HTR2A (0.41) | HTR2AHTR2CHTR2BHTR1ACYP3A4 | |
| SCHEMBL19703128 | 0.82 | HTR2A (0.44) | HTR2AHTR2CHTR2BHTR1ACYP3A4 | |
| SCHEMBL31021971 | 0.82 | HTR2A (0.41) | HTR2AHTR2CHTR2BHTR1ACYP3A4 | |
| SCHEMBL16290528 | 0.82 | MAPT (0.44) | HTR2AHTR2CHTR2BHTR1ACYP3A4 | |
| SCHEMBL29888847 | 0.82 | MAPT (0.44) | HTR2AHTR2CHTR2BHTR1ACYP3A4 | |
| SCHEMBL2111831 | 0.82 | HTR2A (0.41) | HTR2AHTR2CHTR2BHTR1ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024015412-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-01-18 | — | — | WO | disclosed |