SCHEMBL27264183

SCHEMBL27264183

CC(C)(C)OC(=O)N1C(=O)C(CN)CC1(C)C

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
DDB1 Q16531 2/20 0.36
CRBN Q96SW2 2/20 0.36
KDM1A O60341 1/20 0.36
BUB1 O43683 1/20 0.33
CTSK P43235 1/20 0.33
NR1H2 P55055 1/20 0.33
EPHX2 P34913 1/20 0.32
CHRM2 P08172 1/20 0.32
CHRM1 P11229 1/20 0.32
CHRM3 P20309 1/20 0.32
TPSAB1 Q15661 1/20 0.31
TPSD1 Q9BZJ3 1/20 0.31
TPSG1 Q9NRR2 1/20 0.31
GRIN2B Q13224 1/20 0.31
GRIN2C Q14957 1/20 0.31
KDM4E B2RXH2 1/20 0.31
MAPT P10636 1/20 0.31
THRB P10828 1/20 0.31
GPR119 Q8TDV5 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27264198 0.85 DDB1 (0.34) DDB1CRBNKDM1ABUB1NR1H2
SCHEMBL26460839 0.84 DDB1 (0.36) DDB1CRBNKDM1ABUB1CTSK
SCHEMBL26460836 0.81 DDB1 (0.33) DDB1CRBNKDM1AGRIN2BGRIN2C
SCHEMBL26460819 0.77 SPHK1 (0.31) DDB1CRBNKDM1ABUB1NR1H2
SCHEMBL26460815 0.77 SPHK1 (0.31) DDB1CRBNKDM1ABUB1NR1H2
SCHEMBL26460814 0.77 SPHK1 (0.31) DDB1CRBNKDM1ABUB1NR1H2
SCHEMBL24190233 0.76 HSD11B2 (0.35) CTSK
SCHEMBL24189655 0.76 IDO1 (0.46) CTSK
SCHEMBL29015418 0.76 HSD11B2 (0.35) CTSK
SCHEMBL24190004 0.76 IDO1 (0.46) CTSK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024079067-A1 ANTIVIRAL COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2024-04-18 WO disclosed