Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.31 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL27266528 | 0.94 | TDP1 (0.36) | TDP1L3MBTL1GPR84TBXAS1HIF1A | |
| Pyridine SCHEMBL27268596 | 0.79 | TDP1 (0.35) | TDP1L3MBTL1GPR84TBXAS1HIF1A | |
| Hexane SCHEMBL5964926 | 0.69 | TSHR (0.56) | TDP1L3MBTL1TBXAS1HIF1AKCNH2 | |
| Hexane SCHEMBL11222760 | 0.69 | TSHR (0.56) | TDP1L3MBTL1TBXAS1HIF1AKCNH2 | |
| Octane SCHEMBL11323035 | 0.67 | TSHR (0.53) | TDP1L3MBTL1TBXAS1HIF1AKCNH2 | |
| Pyridine SCHEMBL27689622 | 0.67 | TSHR (0.53) | TDP1L3MBTL1TBXAS1HIF1AKCNH2 | |
| Hexadecane SCHEMBL27657619 | 0.67 | TSHR (0.53) | TDP1L3MBTL1TBXAS1HIF1AKCNH2 | |
| Dodecane SCHEMBL3262468 | 0.67 | TSHR (0.53) | TDP1L3MBTL1TBXAS1HIF1AKCNH2 | |
| Tetradecane SCHEMBL27729242 | 0.67 | TSHR (0.53) | TDP1L3MBTL1TBXAS1HIF1AKCNH2 | |
| Heptane SCHEMBL5680251 | 0.67 | TSHR (0.53) | TDP1L3MBTL1TBXAS1HIF1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1031264-C | Preparation of 1,3-dihydro-4-pyridoyl-2H-imidazol-2-ones | MERRELL DOW PHARMA (US) | 1996-03-13 | — | — | CN | disclosed |
| CN-1019197-B | Preparation of 1-3-dihydro-4-pyridinoacyl-2H-imidazol-2-ones | MERRELL DOW PHARMACEVTICALS IN (US) | 1992-11-25 | — | — | CN | disclosed |
| CN-1057261-A | The preparation of 1-3-dihydro-4-pyridine acyl-2H-imidazole-2-ketone compound | MERRELL DOW PHARMACOUTICALS IN (US) | 1991-12-25 | — | — | CN | disclosed |
| CN-1055737-A | The preparation of 1-3-dihydro-4-pyridine acyl-2H-imidazole-2-ketone compound | MERRELL DOW PHARMA (US) | 1991-10-30 | — | — | CN | disclosed |
| CN-85106722-A | Preparation of 1, 3-dihydro-4-pyridinoacyl-2H-imidazol-2-ones | — | 1987-03-25 | — | — | CN | disclosed |