Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 20/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 13/20 | 0.55 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | BLK | P51451 | 1/20 | 0.47 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.47 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.47 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30954374 | 1.00 | CHEK1 (0.55) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| SCHEMBL27280726 | 0.89 | CHEK1 (0.52) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| SCHEMBL24977540 | 0.88 | CHEK1 (0.54) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| SCHEMBL30106185 | 0.88 | CHEK1 (0.54) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| SCHEMBL24977886 | 0.88 | CHEK1 (0.54) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| SCHEMBL30106213 | 0.88 | CHEK1 (0.54) | CHEK1KCNH2NUAK1CHEK2RPS6KB1 | |
| SCHEMBL27280618 | 0.87 | CHEK1 (0.58) | CHEK1KCNH2 | |
| SCHEMBL27312354 | 0.87 | CHEK1 (0.57) | CHEK1KCNH2 | |
| SCHEMBL27312710 | 0.87 | CHEK1 (0.57) | CHEK1KCNH2 | |
| SCHEMBL27312343 | 0.87 | CHEK1 (0.57) | CHEK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024118564-A1 | CHECKPOINT KINASE 1 (CHK1) INHIBITORS AND USES THEREOF | BOUNDLESS BIO, INC. (US) | 2024-06-06 | — | — | WO | disclosed |