Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 17/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13322959 | 0.92 | CHEK1 (0.52) | CHEK1PIM1PIM3 | |
| SCHEMBL2728363 | 0.90 | CHEK1 (0.41) | CHEK1IRAK4PIM1PIM3 | |
| SCHEMBL2727745 | 0.86 | CHEK1 (0.35) | CHEK1IRAK4PIM1PIM3 | |
| SCHEMBL13322999 | 0.84 | CHEK1 (0.42) | CHEK1PIM1PIM3 | |
| SCHEMBL2727017 | 0.81 | CHEK1 (0.46) | CHEK1 | |
| SCHEMBL2728078 | 0.81 | CHEK1 (0.56) | CHEK1PIM1PIM3 | |
| SCHEMBL13322962 | 0.81 | CHEK1 (0.48) | CHEK1PIM1PIM3 | |
| SCHEMBL2727353 | 0.81 | CHEK1 (0.46) | CHEK1 | |
| SCHEMBL2732167 | 0.80 | CHEK1 (0.42) | CHEK1 | |
| SCHEMBL2729777 | 0.79 | CHEK1 (0.46) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2632263-A1 | NOVEL THIAZOLE-CARBOXAMIDE DERIVATIVES AS PDK1 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | claimed |
| WO-2012058174-A1 | NOVEL THIAZOLE-CARBOXAMIDE DERIVATIVES AS PDK1 INHIBITORS | SCHERING CORPORATION (US) | 2012-05-03 | — | — | WO | claimed |
| EP-2632263-A1 | NOVEL THIAZOLE-CARBOXAMIDE DERIVATIVES AS PDK1 INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| WO-2012058174-A1 | NOVEL THIAZOLE-CARBOXAMIDE DERIVATIVES AS PDK1 INHIBITORS | SCHERING CORPORATION (US) | 2012-05-03 | — | — | WO | disclosed |