Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 17/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.58 |
| ▸ | GRM5 | P41594 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9899926 | 0.92 | GCK (0.59) | GCKKCNH2GRM5 | |
| SCHEMBL9898915 | 0.92 | GCK (0.59) | GCKKCNH2 | |
| SCHEMBL2728096 | 0.90 | GCK (0.46) | GCKKCNH2GRM5 | |
| SCHEMBL9896541 | 0.90 | GRM5 (0.56) | GCKKCNH2GRM5 | |
| SCHEMBL9896539 | 0.90 | GRM5 (0.56) | GCKKCNH2GRM5 | |
| SCHEMBL2732434 | 0.89 | GCK (0.54) | GCKKCNH2GRM5 | |
| SCHEMBL2656713 | 0.87 | GCK (0.63) | GCKKCNH2GRM5 | |
| SCHEMBL9899358 | 0.87 | GCK (0.53) | GCKKCNH2GRM5 | |
| SCHEMBL2656193 | 0.86 | GCK (0.62) | GCKKCNH2GRM5 | |
| SCHEMBL9897564 | 0.86 | GCK (0.52) | GCKKCNH2GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445908-A1 | DISUBSTITUTED BENZAMIDE DERIVATIVES AS GLUCOKINASE (GK) ACTIVATORS | Cadila Healthcare Limited (IN) | 2012-05-02 | — | — | EP | disclosed |
| WO-2010150280-A1 | DISUBSTITUTED BENZAMIDE DERIVATIVES AS GLUCOKINASE (GK) ACTIVATORS | CADILA HEALTHCARE LIMITED (IN) | 2010-12-29 | — | — | WO | disclosed |